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InsightHorizon Digest

What causes Anisocoria

Author

Joseph Russell

Updated on April 14, 2026

Generally, anisocoria is caused by impaired dilation (a sympathetic response) or impaired constriction (a parasympathetic response) of pupils. An injury or lesion in either pathway may result in changes in pupil size.

What is anisocoria a symptom of?

Bleeding inside the skull caused by head injury. Brain tumor or abscess (such as, pontine lesions) Excess pressure in one eye caused by glaucoma. Increased intracranial pressure, because of brain swelling, intracranial hemorrhage, acute stroke, or intracranial tumor.

Can anisocoria be harmless?

Simple anisocoria — also called essential anisocoria or physiologic anisocoria — is the most common type of anisocoria. It’s a benign (harmless) condition that affects approximately 20% of the population.

Will anisocoria go away?

Simple anisocoria This is a benign condition that causes the pupils to differ in size, usually by up to one millimeter in diameter, without affecting the pupils’ response to light. This condition can be intermittent or constant, and may even go away on its own without medical intervention.

How do you fix anisocoria?

People with physiological anisocoria do not usually need treatment, as it is typically harmless. Mechanical anisocoria may require surgery to correct the damage a trauma has caused. If the damage is due to an underlying condition, such as uveitis or glaucoma, a doctor will develop an individualized treatment plan.

Is unequal pupil size an emergency?

For new uneven pupil size that is related to new double vision, eyelid droopiness or head, neck or eye pain, it is best to be evaluated in the emergency room.

What cranial nerve causes anisocoria?

Even a blind eye should constrict in response to light shined on the other eye. Unequal pupils (anisocoria) are due to the efferent (motor) system, which includes CNIII, somatic and parasympathetic components, sympathetic nerves originating in the cervical spine, and the smooth muscle of the iris.

What drugs cause dilated pupils?

The most common drugs that can cause dilated pupils are: cocaine, methamphetamine, LSD, and marijuana. Other drugs can cause your eyes to constrict (called miosis); the most common one with this effect is heroin. Alcohol, barbiturates, and heroin can cause diplopia, which is the scientific term for “seeing double.”

Can anxiety make one pupil bigger than the other?

Dilated pupils can occur with any type of anxiety, but are most common during periods of intense anxiety that occur in the following conditions: Panic Disorder/Panic Attacks. PTSD. Phobias.

What drugs cause anisocoria?

Accidental contamination of many drugs, such as cocaine may cause anisocoria. In addition to ocular side effects, cocaine use is associated with a number of complications, involving the cardiovascular, respiratory, neurological, and gastrointestinal systems.

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How common is physiological anisocoria?

Anisocoria that is NOT associated with an underlying medical condition is called physiologic anisocoria. Physiologic anisocoria can occur in 20% of the population. The difference between the sizes of the two pupils is rarely more than 1-2 mm but may vary from time to time.

What causes a blown pupil?

A blown, or blown out, pupil is characterized by a pupil that is largely dilated and unresponsive to light. When it occurs, a fixed dilated pupil may be present in one or both eyes. Typically, blown pupils are seen in response to brain damage caused by trauma or stroke, though less serious causes are possible.

Can drugs make one pupil bigger than the other?

Medications That Affect the Pupils Some medications and illegal drugs can cause your pupils to change size in one or both eyes. Medications that can affect the way your pupils look include: Amphetamines.

What is Tonic pupil?

The tonic pupil, sometimes called Adie tonic pupil or simply the Adie pupil, is the term used to denote a pupil with parasympathetic denervation that constricts poorly to light but reacts better to accommodation (near response), such that the initially larger Adie pupil becomes smaller than its normal fellow and …

Can migraines cause different pupils?

That kind of difference in the size of the pupil — a phenomenon known as anisocoria — could be seen in people with migraines, the doctor told the anxious woman.

What is a Marcus Gunn pupil?

Marcus Gunn pupil (MGP) is the term given to an abnormal pupil showing aberrant pupillary response in certain ocular disorders. In literature, the term is often used synonymously with Marcus Gunn phenomenon or relative afferent pupillary defect (RAPD). [1] After exposure to bright light, a normal pupil constricts.

What is anisocoria cat?

Anisocoria is a condition in which the pupils of the cat’s eyes are different sizes; in other words, one pupil is larger than the other.

What are the symptoms of anxiety?

  • Feeling restless, wound-up, or on-edge.
  • Being easily fatigued.
  • Having difficulty concentrating; mind going blank.
  • Being irritable.
  • Having muscle tension.
  • Difficulty controlling feelings of worry.
  • Having sleep problems, such as difficulty falling or staying asleep, restlessness, or unsatisfying sleep.

Can stress cause pupil dilation?

Stimulation of the autonomic nervous system’s sympathetic branch, known for triggering “fight or flight” responses when the body is under stress, induces pupil dilation.

Does anxiety affect your eyes?

When we are severely stressed and anxious, high levels of adrenaline in the body can cause pressure on the eyes, resulting in blurred vision. People with long-term anxiety can suffer from eye strain during the day on a regular basis.

How long does it take for your pupils to go back to normal after drugs?

It depends on the mydriatic drug (drops to dilate the pupil) used. Typically, the drops used to perform a normal examination of the eye make the pupil dilate very quickly, in about 15 or 20 minutes, and the effect disappears in about an hour and a half.

Does alcohol cause pupils to dilate?

Here’s what happens to our eyes when we drink: Dilated pupils. Because alcohol relaxes muscles all over the body, it causes the pupils to dilate as the muscles in the iris expand.

Does caffeine make your pupils dilate?

According to the outcome of this study, caffeine has paradoxical effects on the intrinsic muscles of the eye: dilating the pupils and increasing accommodative amplitude. This may account for the changes in some visual functions or vision-related task associated with caffeine intake.

What drugs affect vision?

Certain classes of drugs are known to cause eye problems. These include diuretics (water pills), antihistamines, antidepressants, drugs that lower cholesterol, beta-blockers and birth control pills. “Antihistamines often cause a very significant dry-eye syndrome,” Andreoli says.

What drug causes vertical nystagmus?

Vertical, horizontal, or rotary nystagmus may be noted. The most common drug/toxin overdoses that cause nystagmus are the following: Anticonvulsants (phenytoin, carbamazepine, valproic acid, lamotrigine, topiramate)

When is anisocoria abnormal?

One of the most important parts in the evaluation of anisocoria is determining which pupil is abnormal. If the difference in size between the pupils increases in the dark, then the smaller (miotic) pupil may not be dilating well and could be the abnormal one.

Does dilated pupils mean brain damage?

More important, pupil dilation may be an indicator of ischemia of the brain stem. If cerebral blood flow and cerebral perfusion pressure can be rapidly restored in the patient with severe head injury who has dilated pupils, the prognosis may be good.

Is it bad to have dilated pupils?

Dilation, or widening, of the pupils of the eyes is normal in conditions of low light in order to allow more light to reach the retina. Medically, dilation of the pupils is known as mydriasis. Specific medications known as mydriatics are administered to dilate the pupils for ophthalmologic examination.

How do I make my big pupils go down?

Look at a bright, natural light. Stare at a bright window for a couple seconds. This will cause your pupils to shrink immediately. If you’re outside, step into a patch of sunlight, rather than staying in the shadows. While light bulbs will work as well, natural light is more effective.

What is Argyll Robertson pupil?

The Argyll Robertson (AR) pupil has been defined as a pupil that is small and constricts poorly to direct light but briskly when a target within reading distance is viewed (“light-near dissociation”).

How rare is Adie's syndrome?

Adie syndrome is relatively rare, affecting close to 5 in every 100,000 people . It is most common in young adults between the ages of 25 and 45 years and more likely to affect females than males. In most cases, Adie syndrome is idiopathic, which means that doctors do not know the exact cause.